Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience

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Abstract

This article is the second part of a literature review concerning diabetic foot ulcers (DFUs) and the use of antimicrobial photodynamic therapy (PDT). PDT involves the topical application of a photosensitiser into the tissue, followed by illumination that induces the formation of reactive oxygen species (ROS). PDT provides bacterial inactivation and promotes wound healing, and it can be used to manage the infection and microbial colonisation of DFUs. It has pivotal advantages in comparison with chemotherapeutics, such as no potential to induce resistance, and a wide spectrum of activity. Tetracationic Zn(II) phthalocyanine derivatives have been developed for PDT. Among these, we would like to focus on RLP068, whose antimicrobial activity has been widely demonstrated in preclinical studies and in a clinical trial. This article reports previously published evidence and presents four unpublished clinical cases of DFUs treated in the real-life setting with PDT.

Keywords: antimicrobial therapy, diabetes, photodynamic therapy, RLP068, ulcer.

Citation: Pantò F, Adamo L, Giordano C, Licciardello C. Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience. Drugs in Context 2020; 9: 2019-10-3. DOI: 10.7573/dic.2019-10-3

Contributions: All authors contributed equally to the preparation of this review. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest relevant to this manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2020/01/dic.2019-10-3-COI.pdf

Acknowledgments: Content Ed Net provided editorial assistance, with the helpful support of Laura Brogelli, PhD, in the drafting of the manuscript and of Mr Bilal Bham and Hussein Hijazi in the final reading of the manuscript for English language improvement.

Funding declaration: Editorial assistance was funded by Molteni Farmaceutici, Scandicci FI, Italy.

Copyright: Copyright © 2020 Pantò F, Adamo L, Giordano C, Licciardello C. https://doi.org/10.7573/dic.2019-10-3. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2020 Pantò F, Adamo L, Giordano C, Licciardello C. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/efficacy-and-safety-of-photodynamic-therapy-with-rlp068-for-diabetic-foot-ulcers:-a-review-of-the-literature-and-clinical-experience/

Correspondence: Felicia Pantò, Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine, University of Palermo, Palermo, Italy. felicia.panto@unipa.it; Carmelo Licciardello, Unit of Metabolic and Endocrine Diseases, Centro Catanese di Medicina e Chirurgia, Via Battello 48, 95126, Catania, Italy. litoliccia@tiscali.it

Provenance: submitted; externally peer reviewed.

Submitted: 29 October 2019; Peer review comments to author: 21 November 2019; Revised manuscript received: 8 January 2020; Accepted: 12 January 2020; Publication date: 10 February 2020.

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