Clinical use of Capilen, a liposomal cream based on fresh plant extracts enriched with omega fatty acids

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Abstract

The skin is the largest organ in the human body; beyond its regulatory and sensory roles, it is meant to protect and act like a barrier against foreign matter. Products intended to restore the skin health should reintegrate the structure of the stratum corneum in which the corneocytes are surrounded by the intercellular lipid lamellae that maintain both corneum integrity and skin permeability barrier. Capilen is a specific liposomal formulation based on a technology through which highly concentrated fresh plant extracts are conveyed into a jelly-like liposomal vehicle and combined with plant-derived omega-3, -6, -7, and -9 fatty acids, phospholipids, and precursors of ceramides. Its components have been widely investigated and produced clinical benefits in atopic dermatitis, bedsores, scars, inflammatory lesions of the skin, and generally whenever signs of xerosis cutis were present. Liposomes contribute to restore the surface lipid layer of the skin and to deliver substances in the activity site. This liposomal cream was proven to limit and delay the occurrence of radiodermatitis in breast cancer patients, and as an add-on provided complete healing of bedsore lesions in geriatric subjects.

Keywords: liposomal cream, liposomes, omega fatty acids, skin disorders.

Citation: Giacomelli L, Moglia A, Losa G, Quaglino P. Clinical use of Capilen, a liposomal cream based on fresh plant extracts enriched with omega fatty acids. Drugs in Context 2020; 9: 2019-10-1. DOI: 10.7573/dic.2019-10-1

Contributions: Luca Giacomelli drafted the paper. All the authors were involved in the conception of the review, critically revised the drafts, and approved the final version before submission. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: Alessandra Moglia is an employee of Vivendo Pharma, Cham, Switzerland. Edoardo Losa is an employee of Capietal Italia, Bergamo, Italy. Luca Giacomelli is Visiting Professor at the University of Genoa, Department of Surgical Sciences and Integrated Diagnostics, and is also Director Polistudium srl, Milan, Italy. Pietro Quaglino has nothing to disclose. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2019/11/dic.2019-10-1-COI.pdf

Acknowledgments: Editorial assistance was provided by Laura Brogelli, Sara Di Nunzio, and Aashni Shah (Polistudium srl, Milan, Italy), and graphical assistance was provided by Massimiliano Pianta, Freelance Graphic Designer, Pavia, Italy.

Funding declaration: Editorial assistance was funded by Capietal Italia, Bergamo, Italy.

Copyright: Copyright © 2020 Giacomelli L, Moglia A, Losa G, Quaglino P. https://doi.org/10.7573/dic.2019-10-1. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2020 Giacomelli L, Moglia A, Losa G, Quaglino P. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/clinical-use-of-capilen,-a-liposomal-cream-based-on-fresh-plant-extracts-enriched-with-omega-fatty-acids/

Correspondence: Luca Giacomelli, PhD, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy, Corso Europa 30, 16132, Genoa, Italy. lu.giacomelli6@gmail.com

Provenance: submitted; externally peer reviewed.

Submitted: 1 October 2019; Peer review comments to author: 29 October 2019; Revised manuscript received: 12 November 2019; Accepted: 13 November 2019; Publication date: 9 January 2020.

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