Aducanumab: evidence from clinical trial data and controversies

Rajesh R Tampi, Brent P Forester, Marc Agronin

Abstract

Alzheimer’s disease (AD) is the most common cause for dementia worldwide. Until recently, all approved treatments for AD were symptomatic and not disease modifying. On 7 June 2021, the US FDA approved aducanumab, a human IgG1 anti-Aβ monoclonal antibody selective for Aβ aggregates, as the first disease-modifying treatment for AD. Aducanumab is approved in the United States for the treatment of mild cognitive impairment or mild-dementia stage of AD. In this Editorial, we review the trial data for aducanumab in the treatment of AD and the controversies that its approval has generated.

Article Details

Article Type

Editorial

DOI

10.7573/dic.2021-7-3

Publication Dates

Accepted: ; Published: .

Citation

Tampi RR, Forester BP, Agronin M. Aducanumab: evidence from clinical trial data and controversies. Drugs Context. 2021;10:2021-7-3. https://doi.org/10.7573/dic.2021-7-3

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