Small bowel villous atrophy due to immune-checkpoint inhibitors: report of two cases and literature review

Annalisa Schiepatti, Andrea Premoli, Stiliano Maimaris, Mimma Rizzo, Maria Marples, Laura Villani, Nigel Scott, Federico Sottotetti, David S Sanders, Federico Biagi, Clare Donnellan

Article Type

Case Report

Published

This article describes two cases of enteropathy with villous atrophy due to immune-checkpoint inhibitors, which may broaden the differential diagnosis of non-coeliac enteropathies and may represent a pathogenetic model for the understanding of the molecular mechanisms involved in these enteropathies. A narrative review is also provided, summarizing the current evidence on the adverse events of immune-checkpoint inhibitors involving the small bowel.

Read more

Register for alerts

I would like to be contacted by Drugs in Context when new articles are posted.