Challenges and research priorities to progress the impact of antimicrobial stewardship

Article Details

Authors
Matteo Bassetti MD, PhD, Daniele Roberto Giacobbe MD, Antonio Vena MD, PhD, Adrian Brink MMed

Article Type
Review

DOI
10.7573/dic.212600

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Abstract

Antimicrobial stewardship programmes have been playing an important role in patient care and hospital policies. These programmes are now recognised as formal strategies for curbing the upward trend in antibiotic resistance and for improving the appropriate antimicrobial and antifungal use. The role of such programs in the era of antimicrobial resistance presents several unique challenges and opportunities, most notably in the diagnostic and therapeutic setting. Controversies remain regarding the most effective interventions and the appropriate design to evaluate their impact. In this review, based on rounds of discussion, we explain the most important challenges faced by antibiotic stewardship and antifungal stewardship programmes. We also try to suggest areas for further research.

Keywords: antimicrobial stewardship, antimicrobial resistance, AMR, AMS, antifungal stewardship

Citation: Bassetti M, Giacobbe DR, Vena A, Brink A. Challenges and research priorities to progress the impact of antimicrobial stewardship. Drugs in Context 2019; 8: 212600. DOI: 10.7573/dic.212600

Contributions: All authors contributed equally to the conception and overview of the manuscript content, and also contributed equally to the writing of the manuscript. In addition, MB and AB provided critical revision for intellectual content, and oversight. All the authors approved the final version of the manuscript. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosure and potential conflicts of interest: In the past 5 years, M Bassetti has participated in advisory boards and/or received speaker honoraria from Achaogen, Angelini, Astellas, AstraZeneca, Bayer, Basilea, Cidara, Gilead, Melinta, Menarini, MSD, Nabriva, Paratek, Pfizer, Roche, The Medicine Company, Shionogi, Tetraphase, VenatoRX, and Vifor. In the past 5 years, A Brink has participated in advisory boards and/or received honoraria from MSD, Nabriva, and Pfizer. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at https://www.drugsincontext.com/wp-content/uploads/2019/07/dic.212600-COI.pdf

Acknowledgements: None.

Funding declaration: There was no funding associated with the preparation of this article.

Copyright: Copyright © 2019 Bassetti M, Giacobbe DR, Vena A, Brink A. https://doi.org/10.7573/dic.212600. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission.

Correct attribution: Copyright © 2019 Bassetti M, Giacobbe DR, Vena A, Brink A. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0.

Article URL: https://www.drugsincontext.com/challenges-and-research-priorities-to-progress-the-impact-of-antimicrobial-stewardship/

Correspondence: Matteo Bassetti, Clinica di Malattie Infettive, Azienda Ospedaliera Universitaria Integrata di Udine, Piazzale Santa Maria della Misericordia 15, 33010 Udine, Italy. bassetti.matteo@aoud.sanita.fvg.it

Provenance: invited; externally peer reviewed.

Submitted: 19 May 2019; Peer review comments to author: 15 July 2019; Revised manuscript received: 16 July 2019; Accepted: 19 July 2019; Publication date: 19 August 2019.

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