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Respiratory

Mepolizumab: an alternative therapy for idiopathic chronic eosinophilic pneumonia with glucocorticoid intolerance

Authors: Adam Kisling MD, Jason Jones MD, Caleb Hixson DO FCAP, David Hostler MD MPH FACP, Jordanna Hostler MD FACP

This article presents a case of ICEP in which mepolizumab was used as a steroid-sparing agent, resulting in improvement in markers of disease activity
and corticosteroid requirement.

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Can vitamins and/or supplements provide hope against coronavirus?

Authors: Sarah M Michienzi PharmD, Melissa E Badowski PharmD

The goal of this narrative review is to evaluate current and ongoing clinical trials of vitamins and supplements, alone or in combination with each other or other therapies, for the treatment of COVID-19.

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Pharmacological treatment of COVID-19: lights and shadows

Authors: Francesco Menzella MD, Mirella Biava Msc, Chiara Barbieri MD, Francesco Livrieri MD, Nicola Facciolongo MD

The aim of this review is to explore COVID-19 treatment options and describe the potential benefits or disadvantages of their use in severe cases.

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Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Authors: Allan R Brasier MD, Istvan Boldogh DM&B, PhD

This article reviews recent systems-level studies that provide fundamental new insights into how repetitive activation of innate signaling pathways produce epigenetic ‘training’ to induce adaptive epithelial responses and presents studies demonstrating efficacy of these in reducing airway inflammation in preclinical models

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Targeting eosinophils: severe asthma and beyond

Authors: Marco Caminati MD, Francesco Menzella MD, Lucia Guidolin MD, Gianenrico Senna MD

This review summarizes the rationale for the use of biologics in eosinophilic diseases and their mechanisms of action.

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