Early experiences with edoxaban for stroke prevention in atrial fibrillation in the Southeast Asia region

Alejandro Bimbo Diaz, Jeremy Chow, Fan Kee Hoo, Kok Wei Koh, Gary Chin Keong Lee, Wee Siong Teo, Narayanaswamy Venketasubramanian, Chun-Chieh Wang, Radhika Mehta

Article Type

Case Series

Published

The authors share early clinical experiences with once-daily edoxaban and discuss its evidence-based use in patients with non-valvular atrial fibrillation in Southeast Asia through several cases of patients at high risk

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Presentation and pathophysiology of neuro-COVID

Josef Finsterer, Fulvio Alexandre Scorza, Carla Alexandra Scorza

Article Type

Letter-to-the-Editor

Published

Letter to the Editor commenting on Orsucci D, Caldarazzo Ienco E, Nocita G, Napolitano A, Vista M. Neurological features of COVID-19 and their treatment: a review. Drugs Context. 2020;9:2020-5-1.

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Anticoagulation for the prevention of stroke in non-valvular AF in general practice: room for improvement

Adam Ioannou, Sofia Metaxa, George Kassianos, Constantinos G Missouris

Article Type

Original Research

Published

The aim of this study was to assess whether the recommendations and guidelines for thromboprophylaxis in patients with atrial fibrillation (AF) have been adopted in general practice (GP) in the UK. The authors concluded that one in four patients with non-valvular AF, at risk of a stroke, is not being adequately treated with an oral anticoagulant in primary care and suggest that a review of GP practice databases should be considered to identify patients with non-valvular AF, at risk of a disabling or fatal event, and measures taken to initiate anticoagulant therapy.

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Antithrombotic alternatives for stroke prevention in atrial fibrillation: critical differences and remaining questions

James S Kalus

Article Type

Case Report

Published

Apixaban, dabigatran and rivaroxaban all have advantages over warfarin for stroke prophylaxis in patients with atrial fibrillation. In this article the author discusses the effect of organ dysfunction on drug disposition, drug–drug interaction potential, and other patient-centered factors to consider when selecting the right antithrombotic therapy for the patient.

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