Latest research

Cardiovascular consequences of obesity: how will the UK cope?

Cardiovascular consequences of obesity: how will the UK cope?

It is estimated that by 2050, the majority of Britain’s population will be obese. In this article, Dr Henry Purcell discusses the cardiovascular consequences of obesity and what needs to be done to equip healthcare professionals with the tools and training to help prevent and treat weight-related diseases.

Vaccination against meningitis B: is it worth it?

Vaccination against meningitis B: is it worth it?

When a new vaccine is licensed having passed the tests for efficacy and safety, governments who have to pay for it to be used, as in the UK, will carry out a careful economic appraisal before making it generally available. In this challenging article, Dr Peter English discusses whether or not a new vaccine for meningitis that has just been licensed and that could save lives is actually worth it.

Efficacy and safety of duloxetine 60 mg once daily in major depressive disorder: a review with expert commentary

Efficacy and safety of duloxetine 60 mg once daily in major depressive disorder: a review with expert commentary

Major depressive disorder (MDD) is a significant public health concern and challenges health care providers to intervene with appropriate treatment. This review provides evidence that duloxetine 60 mg QD is effective for the treatment of adult patients with MDD in the short- and long-term phases of treatment. Duloxetine 60 mg QD also represents a viable choice of treatment for those patients with painful physical symptoms associated with MDD.

Novel therapeutic modalities and drug delivery in pancreatic cancer – an ongoing search for improved efficacy

Novel therapeutic modalities and drug delivery in pancreatic cancer – an ongoing search for improved efficacy

Pancreatic cancer is a challenging disease due to its high rates of resistance to traditional chemotherapy and radiotherapy. There has been little improvement in the prognosis of pancreatic cancer cases in the past decades, highlighting the need for more effective therapeutic approaches. This article summarizes current developments in targeted pancreatic cancer drug delivery, focusing on delivery systems, targets, and therapeutic agents.

Is ‘GOLD’ standard for the management of COPD in clinical practice?

Is ‘GOLD’ standard for the management of COPD in clinical practice?

Primary therapy for chronic obstructive pulmonary disease (COPD) is the removal of the toxic agent (in most cases, tobacco smoke). Additional therapy includes bronchodilators. Inhaled corticosteroids and long-acting bronchodilators can be used to prevent and reduce the risk of exacerbations. COPD is a systemic disease and often requires therapy of its protean-associated morbidities from depression to osteoporosis and muscle wasting. Despite pessimism from some, COPD is treatable.