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Haematology

Haematology

Drugs in Context Haematology welcomes a broad range of article types including original research, study protocols and review articles.

In line with the principle of providing context for healthcare professionals (HCPs) to properly inform and improve disease management in real world medicine, we especially encourage the submission of articles that provide context for trials of drug interventions in order to motivate improvements in disease management by HCPs practising medicine in the front line.

Advances in iron chelation therapy: transitioning to a new oral formulation

Advances in iron chelation therapy: transitioning to a new oral formulation

Authors: Nirmish R Shah

This review provides an overview of the currently available iron chelator formulations, with a focus on a comparison between deferasirox DT for oral suspension and deferasirox FCT. The new formulation may be associated with fewer side effects and has increased bioavailability. In addition, alternative strategies for iron chelation, such as combining two different iron chelators, will be discussed.

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Human plasma-derived FVIII/VWD concentrate (Biostate): a review of experimental and clinical pharmacokinetic, efficacy and safety data

Human plasma-derived FVIII/VWD concentrate (Biostate): a review of experimental and clinical pharmacokinetic, efficacy and safety data

Authors: Paul Harper, Emmanuel J Favaloro, Julie Curtin, Chris Barnes, Scott Dunkley

Human plasma-derived factor VIII/von Willebrand factor complex concentrates are used to control bleeding in patients with von Willebrand disease (VWD) or haemophilia A (HA). This article provides an extensive overview of the molecular properties, in addition to pharmacokinetic, efficacy and safety data, and case studies of clinical experience of one such concentrate, Biostate.

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A new health-related quality of life instrument for leukemia: will it be widely adopted soon?

A new health-related quality of life instrument for leukemia: will it be widely adopted soon?

Authors: Junhua Yu, Joanna Cheung

Over the last decade, an increasing number of clinical trials in cancer research have been incorporating a health-related quality of life (HRQoL) instrument as part of their trial design. In this article the authors discuss the validity and usefulness of a new HRQoL instrument already in use in the United States.

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Targeting the metabolism of leukemia stem cells as a novel therapeutic strategy

Targeting the metabolism of leukemia stem cells as a novel therapeutic strategy

Authors: Emmanuel A Ho, Neal M Davies

Unraveling our understanding of cancer stem cells and their role in the development and progression of acute myeloid leukemia could lead to improved outcomes.

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