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Cardiology and cardiovascular disease

Cardiac myosin activators for heart failure therapy: focus on omecamtiv mecarbil

Authors: Edgardo Kaplinsky MD, Gordon Mallarkey PhD

This article examines omecamtiv mecarbil, which is a first-in-class cardiac myosin activator used in the treatment of heart failure.

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High-density lipoprotein (HDL) functionality and its relevance to atherosclerotic cardiovascular disease

Authors: Constantine E Kosmas MD, PhD, Ian Martinez MD, Andreas Sourlas, Kyriaki V Bouza MD, Frederick N Campos MD, Verenisse Torres MD, Peter D Montan MD, Eliscer Guzman MD

This review aims to present and discuss the current clinical and scientific evidence pertaining to the significance of HDL functionality over the actual HDL-C concentration in mediating the favorable effects on the cardiovascular system.

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Lipocrinology – the relationship between lipids and endocrine function

Authors: Sanjay Kalra, Gagan Priya

This editorial examines lipocrinology, the study of the interrelationship between lipid metabolism and endocrine function in health and disease

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Manidipine: an antihypertensive drug with positive effects on metabolic parameters and adrenergic tone in patients with diabetes

Authors: Margarita SaizSatjes, Francisco Javier Martinez-Martin

Examines combining a dihydropyridine calcium channel blocker with a renin-angiotensin-aldosterone system inhibitor for the treatment of diabetes

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Lipid-lowering interventions targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): an emerging chapter in lipid-lowering therapy

Authors: Constantine E Kosmas, Eddy DeJesus, Rosmery Morcelo, Frank Garcia, Peter D Montan, Eliscer Guzman

This review aims to present and discuss the current clinical and scientific data pertaining to lipid-lowering interventions targeting PCSK9.

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